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Spontaneous DNA Damage Hydrolysis of the N -glycosyl bond between deoxyribose and a purine in DNA creates an AP site. An AP site generates a thermodynamic destabilization greater than that created by any DNA mismatched base pair. This effect is not completely understood. Examine the structure of an AP site (see Fig. 8-30 b ) and describe some chemical consequences of base loss. | Numerade
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