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Degenerative Mitral Regurgitation (DMR) Progressive valvulopathy from myxomatous degeneration → leaflet prolapse/flail → chronic regurgitation → volume overload & ventricular remodeling. Intervention Criteria (2020 ACC/AHA): · ✅ Symptoms · ✅ LVEF ≤60% · ✅ LVESD ≥40mm · ✅ New AFib or Pulm HTN (PASP≥50mmHg) 2025 Tx Update: · MVr: Gold standard (>95% repair rate, >20-yr durability) · TEER (MitraClip): For high-risk patients · Tendyne TMVR: FDA-approved for severe MAC (May '25) · Early referral to V
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