What is the main cause of cor pulmonale? Write your answer in the comments below ⬇️ Cor pulmonale is right heart hypertrophy, dysfunction or failure. This results in systemic fluid congestion leading to jugular venous distension, hepatomegaly, and edema. The diagnosis of cor pulmonale is usually made with an echocardiogram that shows evidence of increased pressure in the pulmonary arteries and right ventricle. Dive deeper into this topic by watching our video: http://osms.it/cor-pulmonale-fb #os