In vivo CAR T: Faster, cheaper, and more effective cancer care
Dec 16, 2024 · Recent advancements in ex vivo CAR T-cell therapies have revolutionised cancer treatment by harnessing the power of a patient’s own immune system to recognise and fight cancer. Treatment outcomes for large B-cell lymphoma were dismal before CAR T-cell therapies. After two relapses, fewer than 30 percent of patients responded to treatment, and the median overall survival was less than seven ...
Drug Target Review: Leading Research & Insights in Drug Discovery
Stay at the forefront of drug discovery and therapeutic development with Drug Target Review. Dive into the latest research, industry analysis and technological advancements. Connect with world-renowned scientists and explore peer-reviewed articles, webinars, and more.
Tessera Therapeutics: addressing Alpha-1 Antitrypsin Deficiency
Jun 18, 2024 · Mike Holmes, PhD, Chief Scientific Officer at Tessera Therapeutics. Michael joined Tessera in December 2021 as Chief Scientific Officer. Dr Holmes has over 20 years of experience working on the development and clinical translation of different genome editing- and gene therapy-based strategies for the treatment of inherited and acquired diseases.
Euretos - Drug Target Review
We collaborate with the world’s leading pharma, biotech and academic organisations to lower the risks and time frames in disease research and preclinical drug discovery. Euretos provides a unique combination of predictive computational disease models and direct access to our AI-integrated knowledge base of biomolecular databases, literature and patents to evaluate predictions and findings ...
Novel nasal spray effectively prevents influenza infection
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Gene editing for HSV-1 shows significant reduction of viral load
May 15, 2024 · The experimental gene therapy involves injecting a mixture of gene editing molecules into the blood that find where the herpes virus resides in the body. The mixture includes a vector, as well as enzymes. When the vector reaches the clusters of nerves where the herpes virus resides, the enzymes cut the herpes virus’s genes to damage them or remove the virus completely.
CRISPR: three new developments in the world of gene editing
Jan 14, 2021 · A new variant for CRISPR. In a new study, researchers from Michigan Medicine at the University of Michigan, US, revealed that using a novel variant to repair DNA can improve both safety and effectiveness of CRISPR-Cas9 for genetic research.
Publications - Drug Target Review
From January 2024, we will be bidding farewell to the current Drug Target Review magazine and launching a series of innovative offerings for the upcoming year.. Topic-specific eBooks: Delve into key topics and hear more from our editor and industry leaders
White blood cells as a novel early indicator of vaccine efficacy
May 21, 2020 · The authors suggested these findings may be of significance in developing a vaccine against COVID-19 and other viral diseases. Simon Rothenfusser, Department of Clinical Pharmacology, LMU Medical Center and Helmholtz Zentrum München added: “How SARS-Cov-2 triggers an immune response is essentially unknown at the moment.
Immuno-oncology innovations redefining cancer treatment in 2024
Jan 23, 2024 · Dr Espen Basmo Ellingsen. University of Oslo . Dr Ellingsen is a Medical Doctor and holds a PhD in cancer immunology from the University of Oslo. Background in translational research from the Institute for Cancer Research at Oslo University Hospital, focusing on therapeutic cancer vaccination, induced immune responses, and their impact on the tumor microenvironment.