First-in-human trial of ALS therapy ASHA-624 expected in early 2025
Nov 20, 2024 · What is ASHA-624? ASHA-624 was designed using Asha’s PRISM platform to “glue” the SARM1 protein, a central regulator of nerve fiber degeneration, into an inactive …
Mayo Clinic granted $22M to study ibudilast in ALS patient program
Sep 30, 2024 · ALS is a progressive neurological disorder marked by dysfunction and death of motor neurons, the specialized nerve cells that facilitate movement, speaking, swallowing, and …
ALS News Today Home | ALS News Today
4 days ago · Diabetes, high cholesterol linked with lower risk of developing ALS. People with diabetes or high cholesterol may be less likely to develop amyotrophic lateral sclerosis (ALS) …
Highly targeted approach supports ALS gene therapy development
Oct 10, 2024 · Avoiding toxicity “Many potential therapies also alter important cellular processes and this may cause toxicity,” said Fratta. “Therefore, limiting their action to diseased cells, …
Phase 3 trial of oral pridopidine in treating ALS likely this year
Jan 29, 2024 · The HEALEY ALS (NCT04297683) platform trial is designed to simultaneously evaluate multiple experimental ALS treatments against a shared placebo group. It is being led …
Why I can be thankful in the bad situation of life with ALS
Nov 28, 2024 · There’s scientific evidence promoting the benefits of gratitude, so I try to practice it, but I get tired of counting my blessings under the cloud of ALS.My husband, Todd, was …
How 4 wheels and Velcro help me move through my ALS life
Dec 4, 2024 · My ALS symptoms caused me to have weak muscles in my lower legs and feet that affected my balance and ability to walk. So within the first year following my diagnosis, I had to …
MDA 2024: Planned Phase 3b trial aims to show NurOwn's efficacy
Mar 6, 2024 · A pivotal, Phase 3b clinical trial is planned to test the cell-based therapy NurOwn (debamestrocel) in people with amyotrophic lateral sclerosis (ALS), the treatment’s developer, …
Clene granted in-person FDA meeting on CNM-Au8 for ALS
Sep 24, 2024 · Clene has been granted an in-person meeting with the U.S. Food and Drug Administration (FDA) — to be held before the end of November, according to the company — …
Tiziana wins funding for small clinical trial in ALS of intranasal ...
Nov 22, 2024 · The upcoming trial intends to investigate the safety and effectiveness of two foralumab doses in 20 ALS patients. It builds on positive findings from multiple sclerosis (MS) …