In his comic book appearances, Mysterio is the alias of Quentin Beck, a former special effects artist, illusionist and actor who turns to crime. He is one of the superhero Spider-Man 's most enduring enemies and belongs to the collective of adversaries that make up his rogues gallery.

Quentin Beck, aka Mysterio, is one of Spider-Man’s oldest and most iconic arch-enemies. He’s a Hollywood stuntman and FX technician who becomes disillusioned with the industry, and so decides to put his skills to good use as a supervillain instead.