In epidemiology, Mendelian randomization (commonly abbreviated to MR) is a method using measured variation in genes to examine the causal effect of an exposure on an outcome.

Mendelian randomization (MR) is a method of studying the causal effects of modifiable exposures (i.e., potential risk factors) on health, social, and economic outcomes using genetic variants associated …

Apr 22, 2024 · This topic will discuss the rationale and limitations of Mendelian randomization as a study design. The principles of Mendelian inheritance, which are the basis for randomization of this study …

Feb 10, 2022 · Mendelian randomization (MR) is a term that applies to the use of genetic variation to address causal questions about how modifiable exposures influence different outcomes.

Aug 4, 2025 · Mendelian randomization is a research method that uses genetic information to investigate cause-and-effect relationships in human health. It serves as a powerful tool for scientists …

This JAMA Guide to Statistics and Methods reviews the concepts underlying mendelian randomization and provides examples of its application to clinical trial design.

Jul 12, 2018 · We provide explanations of the information typically reported in Mendelian randomisation studies that can be used to assess the plausibility of these assumptions and guidance on how to …

Mendelian randomization (MR) studies have become commonly used in epidemiology to evaluate the causal effect of an exposure (eg, body mass index [BMI]) on an outcome (eg, osteoarthritis [OA]).

This JAMA Guide to Statistics and Methods reviews the concepts underlying mendelian randomization and provides examples of its application to clinical trial design.

Mendelian randomization (MR) is defined as a method that uses genetic variants strongly associated with modifiable exposures to infer causal relationships, minimizing confounding factors that can …