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5 days ago · In this issue of the JCI, Zhu and colleagues integrated functional genomics, single-cell transcriptomics, and analysis of human tumors to show that type I IFN signaling shapes both tumor …
JCI - About the Journal of Clinical Investigation
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JCI - Welcome
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JCI - Deep immunophenotyping reveals circulating activated …
Mar 17, 2025 · JCI Insight. 2016;1 (17):e90045. View this article via: JCI Insight CrossRef PubMed Google Scholar Mankia K, et al. EULAR points to consider for conducting clinical trials and …
JCI - The gut microbiome and cancer response to immune checkpoint ...
Feb 3, 2025 · The field of the microbiome and immunotherapy has skyrocketed since 2015 when two studies demonstrated a fascinating phenomenon in mice: certain gut bacteria could enhance the …
JCI - Induced protein degradation for therapeutics: past, present, and ...
Jan 2, 2024 · View this article via: JCI PubMed Google Scholar Sievers QL, et al. Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4 CRBN activity.
JCI - Antiinflammatory actions of glucagon-like peptide-1–based ...
Nov 3, 2025 · View this article via: JCI Insight CrossRef PubMed Google Scholar Trevaskis JL, et al. Glucagon-like peptide-1 receptor agonism improves metabolic, biochemical, and histopathological …
JCI - Volume 136, Issue 5
5 days ago · Yin et al. report that a macrophage subset expressing activin A facilitates muscle regeneration by acting on satellite cells but contributes to heterotopic ossification in pathological …
JCI - Mechanisms and clinical implications of gut-brain interactions
Jan 2, 2026 · View this article via: JCI CrossRef PubMed Google Scholar Bauer IJ, et al. Visualizing the activation of encephalitogenic T cells in the ileal lamina propria by in vivo two-photon imaging.