More information: Jing Yang et al, MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA, Nature Communications (2025 ...

Another scenario would have been that the mRNA poly(A) tail was fully synthesized prior to nuclear export and was shortened in the cytoplasm. This was actually confirmed in later experiments.

The poly-A tail is a long chain of adenine nucleotides that is added to a messenger RNA (mRNA) molecule during RNA processing to increase the stability of the molecule. Immediately after a gene in ...

This tail is the limiting step for mRNA degradation. “We wondered, why can’t we make multiple tails?” Wang said. “That way, if we lose one, there can be many others.” Wang and her team first ...

During the oocyte-to-embryo transition (OET), the length of the mRNA poly(A) tail is closely linked to its translational efficiency. Regulation of the poly(A) tail is essential for selective ...

Get Instant Summarized Text (Gist) A mechanism regulating mRNA poly(A) tail length in early embryos has been identified, involving the protein MARTRE1, which inhibits the CCR4-NOT complex. MARTRE1 ...