Researchers at the Francis Crick Institute have revealed insight into why embryos erase a key epigenetic mark during early development, suggesting this may have evolved to help form a placenta.

Marsupial research reveals how mammalian embryos form Date: May 14, 2025 Source: The Francis Crick Institute Summary: Researchers have revealed insight into why embryos erase a key epigenetic mark ...

Fig.1 - High-resolution 4C-seq analysis of cohesin/CTCF-mediated interactions. 4C-seq profiles of baits (black spots) anchored at cohesin/CTCF sites in two different genomic regions in control ...

With more research, we may be able to one day replace missing genes in the cells that make sperm to help couples have children through IVF.” Journal Reference: Jeremie Subrini, Wazeer Varsally Irina ...

Reference: Subrini J, Varsally W, Balsells IB, et al. Systematic identification of Y-chromosome gene functions in mouse spermatogenesis. Science. 2025;387 (6732):393-400. doi: 10.1126/science.ads6495 ...

Jeremie Subrini, Wazeer Varsally, Irina Balaguer Balsells, Maike Bensberg, Georgios Sioutas, Obah Ojarikre, Valdone Maciulyte, Björn Gylemo, Katharine Crawley, Katherine Courtis, Dirk G. de Rooij ...

This potentially valuable study reports new and unexpected roles of STAG3 in regulating exit from pluripotency in mouse embryonic stem cells (mESCs). However, the evidence for the proposed role of ...