Non-pharmacological approaches are preferred for promoting sleep in the ICU; however, limited but growing evidence supports the use of pharmacological agents.

Suvorexant belongs to a new class of sleep medications called dual orexin receptor antagonists. Orexin is a molecule that promotes wakefulness; suvorexant blocks it, promoting deeper sleep.

A study from Washington University in St. Louis found taking suvorexant, a common insomnia medication, for two nights slightly decreased amyloid-beta and tau proteins linked to Alzheimer's ...

Recently, a study has shed light on the potential of suvorexant, a drug commonly used to treat insomnia, as a possible tool in the fight against Alzheimer's disease. This finding s ...

Suvorexant dose should be reduced to 5 mg when used along with anti-viral medicines like amprenavir, atazanavir, antibiotics like ciprofloxacin, erythromycin, antifungal medicines like fluconazole ...

More information: Kotaro Hatta et al, Suvorexant for Reduction of Delirium in Older Adults After Hospitalization, JAMA Network Open (2024). DOI: 10.1001/jamanetworkopen.2024.27691 ...

Consistent with expectations, suvorexant showed a trend toward reducing delirium, with only 16.8% of participants exhibiting delirium compared to 26.5% in the placebo group.

Consistent with expectations, suvorexant showed a trend toward reducing delirium, with only 16.8% of participants exhibiting delirium compared to 26.5% in the placebo group.

Suvorexant was also linked to significantly lower delirium rates than was placebo in a post hoc analysis of patients with hyperactive plus mixed subtypes of dementia (10.9% vs 21.6%; P = .04).

The study, published in JAMA Network Open, found that 17% of participants taking suvorexant developed delirium compared with 27% in the placebo group.

According to results, those in the 20 mg suvorexant treatment group registered acutely decreased levels of CSF amyloid beta (A-beta 38/40/42), whereas those given 10 mg suvorexant had a much more ...

Brains from people with heroin use disorder have an increased number of hypocretin (Hcrt, orexin) neurons, which in turn are significantly smaller than in healthy controls. Meanwhile, human narcolepsy ...