Activated AKT phosphorylates TSC1/2 and relieves its inhibition function ... mammalian target of rapamycin complex 1/2; PDK1, phosphoinositide-dependent kinase 1; PI3K, phosphoinositide 3-kinase ...

Plectin drives hepatocellular carcinoma progression and metastasis through cytoskeletal reorganization and oncogenic signaling, making it a promising therapeutic target for overcoming therapy ...

Phagocytosis is a fundamental mechanism used by the body to resist pathogens and restore physiological homeostasis. Herein, to identify small molecules with anti-inflammatory properties via ...

This is a potential best-in-class CDK7 inhibitor for advanced solid tumors ... At Recursion, we were founded around novel insights from complex biology mapping. So essentially building giant ...

Activation of autophagy is antagonized by mTOR inhibition of AMPK, ULK complex, and Class III PI3K complex I and II. mTOR activity is maintained by intracellular leucine, arginine, and methionine ...

By Kolade Adeyemo / Jambar Contributor Breast cancer is one of the most prevalent cancers worldwide, affecting millions of ...

Methods: In this study, we constructed mouse models of SCI and administered PLD inhibitor (FIPI) treatment to investigate ... to the exacerbation and extension of SCI, making it a complex phenomenon ...

Using computational tools and virtual screening, researchers at the Center for Redox Processes in Biomedicine (Redoxoma) have ...

Small-molecule inhibitors targeting viral proteins could serve as an effective alternative for controlling the spread of COVID-19 at both individual and community levels. In this vein, a recent study ...

These insights are paving the way for combination therapies that integrate PI3K inhibitors with immunotherapy and metabolic drugs to improve response rates and durability of treatment. With ...