3-methyladenine (3-MA) and wortmannin (Wm) also inhibit class I phosphatidylinositol 3-kinases (PI3K), but the overall ... The regulation of autophagy is complex and far from understood.

Conversely, mTORC1 can suppress autophagy by inhibiting both ULK1 and beclin-1 complexes ... mTORC, mTOR complex; PGC-1α, peroxisome proliferator-activated receptor γ coactivator-1α; PI3K/AKT, ...

MFN2 in mitochondria interacts with the LD protein PLIN1. Mitochondrial ASCL1 has been found to form a complex with SNAP23 and VAMP4, both present on the LD surface. Moreover, PLIN5 has been found ...

The conclusion that this mutant serves as a dominant negative form of the protein, impacting PI3K complex assembly and IRS/AKT signaling, is important, and the evidence from constitutive and inducible ...

The two, or more, clauses of the sentence still make sense on their own. and complex close complex sentenceA sentence that contains a main (independent) clause and one or more subordinate ...

Background: The Beclin-1/Bcl-2 complex plays a pivotal role in regulating both autophagy and apoptosis in osteoblasts affected by osteoporosis. This study first investigates whether the Bushen Jianpi ...

The term "God complex" is used to describe a person who believes they have exceptional power or authority and are superior to others. It is not considered a mental illness on its own, per the ...

Complex post-traumatic stress disorder (C-PTSD) is a mental disorder that develops in response to complex trauma during childhood. Complex trauma is defined as prolonged exposure to traumatic events ...