Finally, we demonstrated that autophagy is critical for role of PD-1 in regulating VP2 protein expression and IBDV titers. Overall, these findings present a novel mechanism wherein PD-1 induces ...

Article citations More>> Li, W.S., Wang, T.T. and He, W.Q. (2024) Relationship between the PI3K/Akt/mTOR Signaling Pathway and Autophagy Regulation and Related Diseases. Chongqing Medicine, 53, ...

Recently, a phase I/II trial in patients with RCC showed that the autophagy inhibition achieved by hydroxychloroquine enhanced the anti-tumor effects of mTOR inhibitors (Haas et al., 2019). The ...

The PI3K signaling pathway is induced by several growth factors and other hormones. For instance, activation of insulin receptor causes phosphorylation of tyrosine residues in insulin receptor ...

Extracellular matrix (ECM) stiffness is a key stimulus affecting cellular differentiation, and osteoblasts are also in a three-dimensional (3D) stiff environment during the formation of bone tissues.

Further analysis revealed that autophagy enhanced the accumulation of HR-associated DNA repair proteins within the Cas9 complex, which may help direct repair activity toward more precise outcomes.