3-methyladenine (3-MA) and wortmannin (Wm) also inhibit class I phosphatidylinositol 3-kinases (PI3K), but ... is needed for autophagy). The regulation of autophagy is complex and far from understood.

Mitochondrial ASCL1 has been found to form a complex with SNAP23 and VAMP4 ... and their possible contribution to autophagy and phospholipid exchange, communication between mitochondria and lysosomes ...

RAF, PI3K and the RAL guanine exchange factor (RAL ... and NF-κB activation are required for KRAS-induced tumorigenesis. Autophagy counterbalances cellular stress associated with oncogenic ...

The conclusion that this mutant serves as a dominant negative form of the protein, impacting PI3K complex assembly and IRS/AKT signaling, is important, and the evidence from constitutive and inducible ...

The biogenesis of EVs is a complex process that involves multiple cellular pathways ... of protective networks within the cardiovascular system, including the AMPK/PI3K/AKT pathway, transforming ...

The two, or more, clauses of the sentence still make sense on their own. and complex close complex sentenceA sentence that contains a main (independent) clause and one or more subordinate ...

The Phospho-PI3K Tyr458 antibody (#17366) and the PI3K antibody (#4349) were procured from Cell Signaling Technology Co., Ltd. (Massachusetts, United States). In addition, the GAPDH antibody ...

Additionally, CBD induced autophagy through modulation of the PI3K/AKT/mTOR pathway and promoted cellular senescence by upregulating p53 and p21 proteins. In vivo experiments supported these findings, ...

Complex post-traumatic stress disorder (C-PTSD) is a mental disorder that develops in response to complex trauma during childhood. Complex trauma is defined as prolonged exposure to traumatic events ...

1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...