Introduction: To design effective small molecule inhibitors targeting the immune checkpoint PD-1/PD-L1 and to explore their inhibitory activity. Methods: In this paper, a total of 69 PD-1/PD-L1 ...

The dengue virus (DENV) is a single-stranded RNA virus with increasing worldwide prevalence causing severe mosquito-borne viral infections. Therefore, effective strategies to prevent and treat DENV ...

The FDA approval of casimersen was based on the increased dystrophin production observed in patients with DMD who were treated with the drug. 1 The increased production of a functional protein may be ...

The invention described in this patent application relates to oral compounds represented by Formula I. These compounds are designed to specifically target and inhibit KRAS alleles, providing both ...

AOC 1044 provides phosphorodiamidate morpholino oligomers to skeletal muscles and cardiac tissue. Its purpose is to selectively exclude exon 44 of the dystrophin gene, thereby facilitating the ...