This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

On a sunny May afternoon 14 years ago, a group of doctors from across the country gathered in a windowless conference room at the US Food and Drug Administration’s main campus in White Oak, Maryland, ...

Fentanyl, a synthetic opioid 50 times more potent than heroin, is cheaper to produce and easier to smuggle across borders, fueling the illicit opioid epidemic in the United States with devastating ...

WASHINGTON — Veterans who were prescribed an opioid and a benzodiazepine at the same time by the Veterans Health Administration (VHA) faced an increased risk of death, says a new report from the ...

For the first time in two decades, the Food and Drug Administration (FDA) has approved a new class of medication that provides an alternative to addictive opioids for patients looking to manage ...

Washington — Federal officials on Thursday approved a new type of pain drug designed to eliminate the risks of addiction and overdose associated with opioid medications like Vicodin and OxyContin. The ...

Rodin is a clinician scientist and assistant professor of geriatrics and palliative medicine at the Icahn School of Medicine at Mount Sinai. A woman sat in our emergency department in agonizing pain, ...

Opioid overdose deaths have now slowed to the lowest levels nationwide since 2020, according to new estimates from the Centers for Disease Control and Prevention. This marks the 12th straight month of ...

Weight-loss drugs like Wegovy and Zepbound are transforming the health of millions of people—and a new study hints that even more could benefit from the drugs’ other effects on the body. A study ...

Walmart reached a proposed settlement agreement about its distribution of prescribed opioids on Friday according to Security and Exchange Commission (SEC) filings. This settlement includes three ...

Opioid receptors are proteins in the nervous system that interact with opioids. Opioid receptors are part of the endogenous opioid system. This is the body’s internal system for regulating pain, ...

A wildly popular diabetes and weight-loss drug may also protect people from overdosing on opioids. That’s the implication of a new study that examined health records of people with type 2 diabetes and ...