This is a useful study in the role of CHI3L1 in Kupffer cells, the macrophages of the liver, showing that CHI3L1 alters glucose regulation in obesity. Specifically, Chi3l1 protects glucose-dependent ...

A massive U.S. study found diabetics on semaglutide (Ozempic’s active ingredient) had up to 70% lower risk of ...

Importantly, the researchers found that although there was impairment in certain signaling pathways, other components, such as AKT and some of its downstream substrates, remained functional even ...

Insulin resistance (IR) is a complex metabolic disorder characterized by diminished insulin sensitivity, leading to impaired glucose uptake and a potential progression to hyperglycemia and diabetes.

Abstract Background— Recent evidence from cultured endothelial cell studies suggests that phosphorylation of endothelial nitric oxide synthase (eNOS) through the PI3-kinase– Akt pathway increases NO ...

Our research demonstrates that insulin negatively regulates decidualization in hESC via the PI3K/AKT-NR4A pathway. In vivo analysis revealed a significant dysregulation of the AKT-NR4A1 pathway in the ...

In addition, phosphorylated AKT was measured to identify the activation of intracellular pathways as a response to insulin supplementation, as the AKT pathway plays an important role in Influenza ...

Unlike type 1 diabetes, which is an autoimmune disease caused by the patient’s immune system attacking and destroying the pancreas cells that produce insulin, type 2 diabetes is the result of insulin ...

Other molecular pathways associated with energy uptake and utilization are the downstream AKT/mTOR/MAPK pathway and ligand/receptor interactions that initiate cellular signaling through IRS/PI3K.

Keywords: metabolic syndrome, insulin signaling, alzheimer's disease, PI3/Akt pathway, PFT Citation: El Sayed NS, Kandil EA and Ghoneum MH (2021) Enhancement of Insulin/PI3K/Akt Signaling Pathway and ...