If insulin can’t get out of blood vessels, it can’t act in its target tissues. “Endothelial cells are full of insulin ...

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...

Figure 1: The signalling pathway by which insulin inhibits GSK3 and contributes ... 3-phosphoinositide-dependent protein kinase 1; PKB/AKT, protein kinase B; S6K, ribosomal protein S6 kinase.) ...

For this study, the scientists targeted vesicles produced in the brain that ferry several proteins involved in insulin sensitivity—one of which is called Akt. Insulin sensitivity is a measure of ...