A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of ...

A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of ...

For decades, researchers have wondered why some people with risky gene variants go on to develop Parkinson’s disease, while others do not. A new study may have just provided the most detailed answer ...

GetNews Press Release.“ Exosomes Pipeline Insight, 2025 " report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the ...

“This marks a critical shift,” she continued, “away from single-asset risk, toward shared components and repeatable systems.” The designation is a “huge step toward modular, scalable development,” ...

Early endosome maturation requires Rab conversion and ESCRT function; however, how these processes are coordinated remains largely elusive. This study proposes that Rab conversion in both C. elegans ...

The spatiotemporal transition of small GTPase Rab5 to Rab7 is crucial for early-to-late endosome maturation, yet the precise mechanism governing Rab5-to-Rab7 switching remains elusive. USP8, a ...

The findings are useful but do not clearly support the idea that USP8 mediates Rab5-Rab7 exchange and endosome maturation, In contrast, they appear to be incomplete and open new questions regarding ...

Still, mechanistic mysteries remain. “How impaired endosome maturation leads to the formation of TDP-43 inclusions in the cytoplasm and nuclear depletion, whatever comes first, are still important ...

A recent study published in eLife has uncovered a crucial mechanism in cellular material management: endosome maturation. The research team was led by Dr. Ding Mei and Dr. He Kangmin from the ...

Large endosomes become deficient in acidification, maturation arrested, and nonproductive for delivery. This may account for cytotoxicity of LNPs.