Now, with revived hope that clemastine – or a similar, yet-to-be developed drug – may restore some function, Green believes it’s time for neurologists to shift attention away from canes and ...

WEST PALM BEACH, Fla. — Treatment with clemastine fumarate was linked to accelerated disease and disability progression due to pyroptosis in a small cohort of individuals with multiple sclerosis ...

“Clemastine can only be partially effective at the doses we can use,” said Green, who is also a neuro-ophthalmologist and chief of the Division of Neuroimmunology and Glial Biology in the UCSF ...

Clemastine is detected in brain tissue following systemic injection: MALDI-MS spectra of clemastine standard (a) and tissue homogenates from the left hemisphere (b–d) from 3 rat brains (P6, P12 ...

“Clemastine can only be partially effective at the doses we can use,” Green said. “It can be sedating, which may be especially undesirable in patients with MS.

Clemastine fumarate is one of four drugs in the ongoing TRAP-MS phase 1/2 trial, which is sponsored by NIAID. The study is designed to determine what effects, if any, the drugs have on MS ...

Clemastine fumarate may promote remyelination -- even in patients who have pre-existing injury -- suggest full results from the ReBUILD trial.

Clemastine fumarate was first approved by the Food and Drug Administration (FDA) in 1977. It is an antihistamine medication for allergies and has been available over the counter since 1993.

Clemastine(Allerhist-1 and Tavist-1) generic is an antihistamine and anticholinergic agent, prescribed for allergic rhinitis. It is also used for uricaria and angioedema. This medication inhibits ...

Clemastine works in this setting by stimulating the differentiation of myelin-making stem cells. This places the medication a generation ahead of existing MS drugs that work by dampening the ...