Clemastine fumarate (CLM), an antihistamine medication, escalates disease progression in progressive multiple sclerosis (MS) by amplifying innate immune responses, particularly through P2RX7-mediated ...

Clemastine fumarate, an antihistamine, boosted disease progression by more than five times in adults with progressive multiple sclerosis (MS), according to data from a Phase 1/2 trial.

As brain samples donated by people with Williams Syndrome also show impairments in myelination, Barak and his team plan to repurpose clemastine as a potential treatment for the condition.

Remyelination trials have demonstrated the potential benefits that therapeutics, such as clemastine, can bring to patients with MS even when drugs do not meet clinical end points, explained Ari ...

How Clemastine - An Antihistaminic, Led to the New Drug! The original breakthrough came when Chan invented a method to screen drugs for their ability to instigate remyelination.

They also found that clemastine’s benefits came from blocking just one of the five muscarinic receptors, M1R, but the effect on M1R was middling, and the drug also affected the other receptors. The ...

Clemastine's benefits begin with its effect on oligodendrocyte precursor cells (OPCs). These cells stay dormant in the brain and spinal cord until they sense injured tissue.

Clemastine's benefits begin with its effect on oligodendrocyte precursor cells (OPCs). These cells stay dormant in the brain and spinal cord until they sense injured tissue.

Clemastine's benefits begin with its effect on oligodendrocyte precursor cells (OPCs). These cells stay dormant in the brain and spinal cord until they sense injured tissue.

This single-center, prospective, noninferiority study compares a historic cohort receiving a premedication regimen with intravenous clemastine to a prospective cohort receiving oral cetirizine.