Extracellular vesicles have emerged as promising tools in regenerative medicine due to their inherent ability to facilitate intercellular communication and modulate cellular functions. These nanosized ...

When S-nitrosylation of CaMKII is reduced, it stops working as well in the brain. The team discovered that this alone is enough to interfere with synaptic plasticity, which is the brain’s ...

In this case, overexpression of p-ERK and down expression of p-AMPK after incubation with EWD at all time points was observed. The peptide induced an increase in ERK phosphorylation at 5 and 15 min ...

High-stiffness ECM activates the mechanosensitive ion channel Piezo1, triggering Ca² + influx, activating the CaMKII/CREB signaling pathway, inducing Osr2 expression, and driving T-cell exhaustion.

Tumors with mutant BRAF and some with mutant RAS are dependent upon ERK signaling for proliferation, and their growth is suppressed by MAPK/ERK kinase (MEK) inhibitors. In contrast, tumor cells with ...

ERK1 and ERK2 are the primary members of the ERK family. Upon activation, phosphorylated ERK (P-ERK) phosphorylates hundreds of cytosolic targets, including cytoskeletal elements (e.g., microtubules, ...