Renal fibrosis is one of the main pathological features of chronic kidney disease (CKD), and its treatment has been a hot research topic. Recent studies have shown that stem cell therapy can repair ...
GA protects endothelial cells by increasing GSH levels and DNMT1 expression to reduce apoptosis, while improving mitochondrial function by inhibiting the ERK/CypD/NOX4 pathway. It also inhibits ...
Transient Ca 2+ fluctuations on the surface of the endoplasmic reticulum (ER) can induce liquid-liquid phase separation (LLPS) of the autophagy initiation complex FIP200, forming FIP200 puncta and ...
From Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, Victoria, Australia (R.H.R.) Division of Endocrinology and Metabolism (E.D.A.), ...
Supply Chain. Neuronal activity triggers an influx of calcium in postsynaptic mitochondria, which jolts CaMKII and CREB (inset). This prompts transcription of OXPHOS genes and production of ATP, which ...
Mesoblast (ASX:MSB) was the top performer for the year up 835% (as of December 30). On December 18 Mesoblast announced that the US Food and Drug Administration (FDA) had finally approved its therapy ...
ABSTRACT: Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key regulator of heart function. While some CaMKII activity is beneficial, excessive, or persistent, CaMKII can lead to heart ...
ABSTRACT: Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key regulator of heart function. While some CaMKII activity is beneficial, excessive, or persistent, CaMKII can lead to heart ...
During the peer-review process the editor and reviewers write an eLife assessment that summarises the significance of the findings reported in the article (on a scale ranging from landmark to useful) ...
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