Objective To assess the comparative efficacy of traditional non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclo-oxygenase-2 inhibitors in patients with acute gout. Design Systematic ...

NSAIDs stop proteins called cyclooxygenase, known as COX, and fall into two classes: “selective” COX-2 inhibitors (celecoxib, etoricoxib, or rofecoxib) and “nonselective” COX-1/COX-2 ...

This paper showcases a novel 2.5D architecture-based dual-band multifunctional active frequency selective surface (AFSS). The designed AFSS exhibits passband filter response in the transmission mode ...

Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain homeostatic functions and mediate pathogenic mechanisms, including the inflammatory response. They are generated ...

Overwhelmingly, the selectivity of NSAIDs is based on an IC 50 value (the concentration at which an NSAID produces 50% inhibition of COX-1 and/or COX-2).

This simplistic division of the roles of COX-1 and COX-2 drove the search for 'selective' COX-2 inhibitors and further fuelled the ranking of NSAIDs in terms of their relative selectivity for COX ...

Selective CO 2 Adsorption in Ultrahydrophobic Molecular Pyrene Frameworks by Computational Design Sam D. Harding Tao Liu Linjiang Chen ...

Swedish Ambassador to Bangladesh Nicolas Weeks today (19 June) announced an additional $2.1 million or Tk25.7 crore to save lives and support the green return to Cox's Bazar. The contribution, ...

An iterative parallel synthesis effort identified a PLD2 selective inhibitor, ML298 (PLD1 IC50 > 20 000 nM, PLD2 IC50 = 355 nM) and a dual PLD1/2 inhibitor, ML299 (PLD1 IC50 = 6 nM, PLD2 IC50 = 20 nM) ...

"NSAIDs work by inhibiting cyclooxygenase enzymes (COX-1 and COX-2) throughout the body," he noted, which means they inhibit the production of "biological mediators" that cause inflammation and ...