It is unclear if COX-2-selective NSAIDs also inhibit COX-3 and whether this inhibition could represent a primary central mechanism by which these drugs decrease pain and possibly fever.

Basically, they increase the pain you feel. NSAIDs work on a chemical level. They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in ...

Celebrex (celecoxib) is a selective NSAID. It differs from non-selective NSAIDs because it targets the COX-2 enzyme, ...

Meloxicam is also a selective COX-2 inhibitor, reducing the risk of GI side effects compared to naproxen. However, NSAIDs ...

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...

NSAID research changed radically with the discovery that COX existed in two isoforms: the constitutively expressed COX-1 and an inducible COX-2 isoform 6. Analysis of the distribution of these ...

NSAIDs are the principal agents used for managing pain in patients with chronically painful diseases, such as osteoarthritis. However, the withdrawal of the selective cyclo-oxygenase 2 (COX2 ...

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...

In the third episode of the NSAIDs saga, we focus on COX-2 inhibition! Did the hopes and dreams of selective COX-2 inhibition pan out? What can the rise and fall of VIOXX teach us about physiology?

Effects of COX-2-selective NSAIDs on Vascular Endothelium: Class or Individual Effect? To date, the mechanism of increased cardiovascular risk associated with COX-2-selective NSAIDs remains ...