The sole clinical symptom of the patient was polyurea. The infiltration of leukemic blasts into the kidney can lead to nephrogenic diabetes insipidus in patients with acute lymphoblastic leukemia (ALL ...

Patients with hemophilia-affected joints had more difficulty performing usual activities and reported a higher incidence of mobility issues. A recent multinational survey highlighted the significant ...

Participants with maximal lifetime brain growth above the median experienced smaller changes in their EDSS scores over the study period. A new study has revealed that a larger maximal lifetime brain ...

The study's reduced mean diagnostic delay of 1.8 years suggests increased disease awareness could improve outcomes in this multisystemic condition. A new analysis of data from the EMPATIa study in ...

Hydroxychloroquine initiated concurrently with standard induction therapy behaved as an independent factor for remission and improved patient survival. A new Chinese study has found increased rates of ...

Patients with abnormal numbers of CD3 + T cells had considerably higher mortality and recurrence rates. The immune system and especially the B cells of patients with acute lymphoblastic leukemia (ALL) ...

In relapsed ALL cases, the most prominent source of new mutations was exposure to thiopurine Multiple mutational processes usually act in parallel as prominent secondary drivers with dynamic activity ...

A diagnosis of ATTR amyloidosis should be considered in elderly patients with anemia and endoscopic evidence of multiple colorectal ulcers and/or erosions. In Cureus, physicians presented the case of ...

The biopsy showed infiltrated of atypical CD20 positive lymphoid cells suggestive of high-grade diffuse large B cell lymphoma or PCNSL. A case of primary central nervous system lymphoma (PCNSL) ...

Misdiagnosis as chronic inflammatory demyelinating polyneuropathy is common with the Gly103Arg variant of vATTR, especially in patients unresponsive to traditional treatments. The Gly103Arg variant of ...

Only 0.4% of patients on rIX-FP failed to reach the target trough, compared to 59.3% to 71.9% for rFIXFc, depending on the administration schedule, and 79.9% for rFIX. Researchers have developed a ...

In a rat model of MPO-AAV, MOD06051 reduced neutrophil extracellular trap deposition in renal tissues and ameliorated disease symptoms. Inhibition of cathepsin C showed promise as a therapeutic ...