A historic College Football Playoff semifinal kicks off at the Orange Bowl as Notre Dame and Penn State square off with a shot at the national championship game

Get our expert betting predictions for the evenly-matched CFP semifinal clash between Notre Dame and Penn State.

Just four teams remain in pursuit of a college football national championship. It all gets underway later tonight, when Notre Dame takes on Penn State in the Orange Bowl. The winner of that game will face the winner of Friday night’s Cotton Bowl Classic between Texas and Ohio State.

Our college football expert has whipped up a three-leg same game parlay for Thursday's Notre Dame vs. Penn State College Football Playoff semifinal.

The Fighting Irish opened as favorites against the Nittany Lions for the semifinal set to take place in the Orange Bowl. Notre Dame opened as a 2.5-point favorite, but the spread is -1 on the day of the game.

Members of the Notre Dame Fighting Irish are reportedly battling a flu outbreak in their locker room ahead of Thursday's College Football Playoff semifinal.

Here's a look at the series history between Penn State and Notre Dame heading into their College Football Playoff semifinal matchup.

Notre Dame players and staff members are dealing with a "flu or a virus" ahead of Thursday night's College Football Playoff semifinal against Penn State, a school official confirmed in a statement to CBS Sports' Brandon Marcello.

Though the two teams haven't met since 2007, Penn State and Notre Dame share a history that includes a number of notable clashes.