During the oocyte-to-embryo transition (OET), the length of the mRNA poly(A) tail is closely linked to its translational efficiency. Regulation of the poly(A) tail is essential for selective ...

Get Instant Summarized Text (Gist) A mechanism regulating mRNA poly(A) tail length in early embryos has been identified, involving the protein MARTRE1, which inhibits the CCR4-NOT complex. MARTRE1 ...

What about an mRNA vaccine for H5N1? There isn't one yet, but several companies—including Moderna, Pfizer and GlaxoSmithKline (in collaboration with CureVac)—are working on such a shot.

In this article, we are going to take a look at where Moderna Inc. (NASDAQ:MRNA) stands against other firms end 2024 stronger with impressive gains. A lackluster trading persisted throughout the ...

translation and degradation that result from the presence of a stem–loop rather than a poly(A) tail at the 3′ end of the mRNA. In addition, we do not yet understand the precise signalling ...

Indeed, mRNA-4157 (V940) was given alongside the current standard of care, which includes another form of immunotherapy, a drug known as Keytruda (pembrolizumab). Moderna and Merck announced in ...

Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, ...

All the Fairy Tail 100 Years Quest episodes are here to quench your thirst for more magical adventures with Natsu, Lucy, Erza, and the rest of the crew. Picking up one year after the original series’ ...

A global international trial of an mRNA vaccine against norovirus is getting underway with the aim of reducing the health burden caused by the infamous “winter vomiting” bug. The trial has ...

Surprisingly, this mRNA shortening does not appear to require the shortening of poly A tails. These are novel, paradigm-shifting findings, using cutting-edge technologies and convincing data, that ...

This cover highlights the article ZBTB48 is a priming factor regulating B-cell-specific CIITA expression by Grishma Rane, Dennis Kappei and colleagues. The study identifies how ZBTB48, represented as ...