Things haven't been easy for the San Francisco 49ers on Sunday at Levi's Stadium against the Tennessee Titans. They had a ton of offensive success in the first half, but their 5.6 yards ...

San Francisco 49ers QB Brock Purdy's quick throw to TE George Kittle resulted in a 24-yard gain in the team's Week 15 matchup.

Set up with a nice catch and run from Ricky Pearsall, Brock Purdy found WR Jauan Jennings for the pair's second touchdown of ...

San Francisco 49ers quarterback Brock Purdy throws to tight end George Kittle who gains 24 yards against the Tennessee Titans ...

San Francisco 49ers RB Christian McCaffrey capped the drive with a one-yard rushing touchdown against the Tennessee Titans.

San Francisco 49ers quarterback Brock Purdy connects with tight end George Kittle on back-to-back plays against the Tennessee ...

The Tennessee Titans aim for their third road victory of the season with a trip to the San Francisco 49ers on Dec. 14 in Santa Clara, California. Tennessee (2-11) snapped a seven-game losing streak by ...

The Buffalo Bills aren't ready to relinquish the AFC East crown just yet, roaring back from 17 points down at the half to defeat the New England Patriots 35-31. Down 24-7, the Bills scored 28 points ...

The Niners officially placed Aiyuk on the NFL’s reserve list on Saturday, with a “left squad” designation. It’s an incredibly ...

Just 24 hours before their Week 15 matchup vs. the Tennessee Titans, the San Francisco 49ers got a concerning update on ...

NFL Week 15 is here and we asked USA TODAY Sports' staff for their top bets for the entire NFL slate. Here are their picks ...

The Athletic's Dianna Russini is expecting an answer in the near future as to whether Brandon Aiyuk will play another game ...