The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps")—and about 150 proteins, involved in different stages of ...

The spliceosome then converts them into mature, functional mRNA. To do this, this large protein-RNA complex, which is located ...

The spliceosome edits genetic messages transcribed from DNA, allowing cells to create different versions of a protein from a single gene. The vast majority of human genes -- more than nine in ten ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

The spliceosome is the collection of 150 different proteins and five small RNA molecules that orchestrate the RNA editing process, but until now, ...

Precursor messenger RNA is edited into its final form by an RNA–protein assembly called the spliceosome. Structural evidence provides insights into how the spliceosome is disassembled when its ...

How this system of broken genes and the spliceosome evolved in our genomes is not known. Over his long career, Manuel Ares, UC Santa Cruz distinguished professor of molecular, cellular, and ...

Spliceosome assembly in yeast extracts also could occur by interaction of the U1 snRNP with the pre-mRNA, followed by a tetra-snRNP joining to form a functionally identical particle. (Reprinted with ...

Wan Ruixue is a researcher and a supervisor of Ph.D. students with the School of Life Sciences at Westlake University, in East China's Zhejiang Province. She has made important contributions to ...

The spliceosome edits genetic messages transcribed from DNA, allowing cells to create different versions of a protein from a single gene. The vast majority of human genes – more than nine in ten ...