Uncovering a new genetic code in archaea opens doors for bioengineering applications

The genetic code is the recipe for life, and provides the instructions for how to make proteins, generally using just 20 ...

DNA transcription is a tightly choreographed event: How RNA polymerase II regulates the dance

Life's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing ...
eLife

TSvelo: Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription and splicing

This study presents a valuable tool named TSvelo, a computational framework for RNA velocity inference that models transcriptional regulation and gene-specific splicing. The evidence supporting the ...
eLife

Apparent cooperativity between human CMV virions introduces errors in conventional methods of calculating multiplicity of infection

Whether infection of cells by individual virions occurs randomly or if there is some form (s) of competition or cooperativity between individual virions remains largely unknown for most virus-cell ...
C&EN

These archaea built a distinct genetic code to put pyrrolysine in proteins

Pyrrolysine is an important component of methyltransferase enzymes, which the archaea use to metabolize methylamine in the environment. “The need for that metabolism and availability of the machinery ...