PI3K signalling mediates responses to a myriad of cues ... Results from 4 healthy controls (WT; 1-4), 1 patient with Activating p110 Delta Syndrome 2 (APDS2) due to the p85α Δexon11 variant, and 3 ...
1 Itovebi is a highly potent and selective inhibitor of the alpha isoform of the p110 catalytic subunit of the PI3K complex. The oral targeted therapy has demonstrated best-in-class potential, with a ...
By doing so, only the shedded (cleaved form) p110 HER2 ectodomain may be recognized. This may, in turn, improve the specificity of a serum HER2 assay by identifying only that soluble HER2 variant ...
In 1987 I attended a meeting at Cold Spring Harbor on phosphatidylinositol signaling that turned out to be pivotal for me. A few years earlier I'd helped show that a phosphatidylinositol (PI) kinase ...
Nevertheless, the roles of miR-133 in cardiac remodeling are ambiguous, and the mechanisms are also sophisticated, involving many target genes and signaling pathways, such as RhoA, MAPK, TGFβ/Smad, ...
Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells do not express ...
1 Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, the Netherlands 2 Department of Experimental Internal Medicine, Academic Medical Centre, Amsterdam, the Netherlands ...