Conversely, mTORC1 can suppress autophagy by inhibiting both ULK1 and beclin-1 complexes ... mTORC, mTOR complex; PGC-1α, peroxisome proliferator-activated receptor γ coactivator-1α; PI3K/AKT, ...

MFN2 in mitochondria interacts with the LD protein PLIN1. Mitochondrial ASCL1 has been found to form a complex with SNAP23 and VAMP4, both present on the LD surface. Moreover, PLIN5 has been found ...

FILE - A boy rides his bicycle past apartment buildings as a rally staged by the East Colfax Community Collective is held in the courtyard to address chronic problems in the apartment buildings ...

The original version of this story appeared in Quanta Magazine. Ten years ago, the European Space Agency’s Rosetta probe pulled up alongside a dusty, icy lump the size of a mountain. The probe ...

During a Case-Based Roundtable® event, Catherine Coombs, MD, discussed the BRUIN trial and recent NCCN updates on chronic ...

The two, or more, clauses of the sentence still make sense on their own. and complex close complex sentenceA sentence that contains a main (independent) clause and one or more subordinate ...

Disrupting the Beclin-1/Bcl2 complex using BH3 mimetics, such as ABT-737, restores autophagic activity and induces cancer cell death (35). Additionally, small molecule inhibitors that disrupt the ...

The term "God complex" is used to describe a person who believes they have exceptional power or authority and are superior to others. It is not considered a mental illness on its own, per the ...

Future Microbiol. 2012;7(6):719-731.

Complex post-traumatic stress disorder (C-PTSD) is a mental disorder that develops in response to complex trauma during childhood. Complex trauma is defined as prolonged exposure to traumatic events ...