New research identifies the class II PI3K-C2b protein, a member of the PI3 family of kinases, as one of the key regulators of blood vessels growth in humans and other mammals. Mutations in these ...

An AI called AlphaFold predicted structures for nearly every protein known to science. Those predictions aren’t without limits, some researchers say.

However, it also has a second mode of action which triggers the breakdown of the mutated PI3K alpha protein, destroying it altogether—a process known as targeted protein degradation.

A second drug candidate, BBO-10203, blocks the interaction between RAS and PI3K alpha, a family of enzymes involved in cellular growth and proliferation.

With positive first-in-human findings on board, Relay Therapeutics Inc. plans a pivotal study next year to test RLY-2608, an allosteric, pan-mutant and isoform-selective inhibitor of PI3K alpha in ...

Researchers have discovered that plant-derived phytochemicals and their gut microbiome metabolites control the effectiveness of PI3K inhibitors in cancer therapy. The study reveals that dietary ...

The transcription factor retinoid X receptor-alpha (RXRα) can also form homotetramers. Here the authors show that the anti-cancer agent K-80003 selectively inhibits the nongenomic action of N ...

AlphaFold solved a structural biology riddle: predicting protein structure. And yet, CASP, a global competition born to solve that problem, lives on.

Move over, chatbots. This upgraded AI can model antibodies, DNA, and molecules from disease organisms. This next generation of AlphaFold, from Google Deepmind, is poised to significantly advance ...

The protein expression of p-4E-BP1/ Cyclin D1/ CDK4 may present a biomarker for selecting advanced breast cancer patients who will benefit from the combination of PI3K/mTOR inhibitors and CDK4/6 ...

DeepMind says its AlphaFold AI has made a massive scientific breakthrough by predicting the structure of more than 200m proteins.