In 2005, Piramed licensed its PI3K inhibitors focusing on the alpha form to Genentech for use in cancer, in a $230 million deal – one of the largest preclinical collaborations ever signed by a UK ...

Original Paper Published: 28 September 2000 Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways Elena V Rusyn ...

The Alphafold machine learning system for predicting a protein’s structure from its amino acid sequence has been adapted to make it possible to design de novo proteins that fold in a particular way ...

The latest version of Google DeepMind and Isomorphic Labs’ AlphaFold model can predict the structure and relationships not only of proteins, but “all of life’s molecules”, according to its ...

When Alphabet announced in 2021 that its AlphaFold AI could predict the structure of almost every known protein, it was a major story, not just in the pharma world, but beyond. Yet, that was far ...

Eli Lilly acquired Scorpion earlier this year to get one drug, a PI3K alpha inhibitor in Phase 1/2 testing for breast cancer. Boston-based Antares spun off from Scorpion with the rest of that ...

A population of stromal cells that retains osteogenic capacity in adult bone (adult bone stromal cells or aBSCs) exists and is under intense investigation. Mice heterozygous for a null allele of ...