The authors show that mouse or human tumours in which the PI3K/Akt pathway is constitutively activated are resistant to dietary restriction whereas other tumours are sensitive. The authors also ...

These findings thus provide suggestive evidence that PI3K/AKT activation may result from other events, such as mutation or gene amplifications of membrane receptors, overexpression of growth ...

The latest research published in Genes & Diseases unveils groundbreaking insights into the role of the aging process and the ...

It has been shown in vitro that PI3K mutations may confer increased resistance to EGFR inhibition. 39 Two head and neck cancer cell lines with canonical PIK3CA mutations were largely insensitive to ...

This finding suggests these cancers may have been driven by tamoxifen-induced activation of the phosphatidylinositol 3-kinase (PI3K) pathway, researchers concluded.

A pairing of two experimental drugs inhibits tumor growth and blocks drug-induced resistance in ovarian cancer, according to ...

As expected by what is known about PI3K pathway regulation, hyperactive PI3K signaling triggered a negative feedback mechanism to suppress pathway activation by growth factor signals.

In addition, PI3K/mTOR activation and suppression of autophagy in the early stages of patients with HPV16 infection are crucial for viral entry and infection. 22 Following HPV infection, the PI3K ...

Because induction of collagen synthesis is associated with phosphatidylinositol 3-kinase (PI3K) activation, we designed a FAP-targeted PI3K inhibitor that selectively targets FAP-expressing human IPF ...

Most patients with gastric cancer are diagnosed in advanced stages of the disease. Target identification and unveiling the molecular mechanisms behind it are crucial for this field.

The latest research published in Genes & Diseases unveils groundbreaking insights into the role of the aging process and the ...