In short, preclinical models may not necessarily permit the detection of context-specific activation of PI3K (or other effectors) by mutant KRAS. Tissue specimens from patients treated with KRAS ...

More information: Toshinori Yoshioka et al, Delta opioid receptor agonists activate PI3K–mTORC1 signaling in parvalbumin-positive interneurons in mouse infralimbic prefrontal cortex to exert ...

In a paper published in Science Bulletin, a Chinese team of scientists reported a comprehensive proteogenomic analysis of 101 Chinese AML patients, including proteomic and phosphoproteomic analyses ...

Next, researchers analyzed the mTOR signaling-related protein activation in brain regions ... anti-depressive effect was produced through the PI3K and mTOR pathway. The IL-PFC in rodents is ...

This way, JANX can generate bispecific therapeutics that precisely activate parts of the tumor ... mutations with mCRPC patients with AR, PI3K, BRCA1/2, or TP53 mutations. Here, JANX007 obtained ...

During puberty, branching morphogenesis is initiated by GH, estrogen, and IGF1. Intriguingly, GH, estrogen and IGF-1 are all involved in the activation of the PI3K/Akt signaling pathway. Breast cancer ...

Its activation then triggers a broad spectrum of downstream cascades to promote numerous effects, including cell growth, proliferation, and survival. PI3K/Akt is one of the most well studied pathways ...