It has been highlighted by Clarivate for its potential ability to preserve the function of insulin-producing beta cells in the pancreas and delay the need for insulin treatment; 14) Valoctocogene ...

M2a macrophages are stimulated by IL-4 or IL-13 to generate and secrete pro-fibrotic substances like TGF-β, insulin-like ... STAT signaling pathway, NF-κB signaling pathway, phosphoinositide 3-kinase ...

PI3K/Akt is one of the most well studied pathways activated by HER2 ... IGF-binding protein-3; IGFR, insulin-like growth factor receptor; MAPK, mitogen-activated protein kinase; PI3K, ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

The hormone insulin plays a central role in the metabolism of many living organisms. When food is plentiful, insulin promotes ...

Reciprocally, iron influences insulin action. Iron interferes with insulin inhibition of glucose production by the liver. Hepatic extraction and metabolism of insulin is reduced with increasing ...

Multiple molecular pathways play a role in gastric cancer development, influencing how genetic and environmental factors interact to drive tumor growth and progressiA recent study by researchers at ...

A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell.

Most, if not all, of the pathways that are crucial for cancer development and progression affect translational control. These include the selective translation of mRNAs encoding proteins that are ...

The discovery and development of GLP-1 receptor agonists for type 2 diabetes and obesity is a bench-to-bedside success story.1 Multiple GLP-1 receptor agonists are now in clinical use, such as ...

In amongst a clutch of discontinued phase 3 programmes in Roche's fourth-quarter results update was the news that it has stopped a study of AKT inhibitor ipatasertib as a treatment for first-line ...