Hu and colleagues showed a protein controlling the PI3K/Akt pathway, a pathway targeted by more than 40 anti-tumor drugs, is absolutely required for the synthesis, processing and secretion of insulin.

Hu and colleagues showed a protein controlling the PI3K/Akt pathway, a pathway targeted by more than 40 anti-tumor drugs, is absolutely required for the synthesis, processing and secretion of insulin.

KEY POINTSThe PI3K/AKT/mTOR pathway is an established oncogenic driver in a variety of tumor types.Inhibitors of this pathway are already in clinical testing, ... however, an intriguing class effect ...

IRF1 was also found to be associated with the impairment of the insulin/IGF signaling pathway. Previous studies have linked the expression of IRF1 with male sex, older age, diabetes, and COVID-19.

AKT is related to the regulation of the insulin and insulin-like growth factor (IGF-1) pathways, and has also been found to affect lifespan in other model organisms.

(Medical Xpress) -- Researchers at the Stanford University School of Medicine have identified a molecular signaling pathway that drives the growth and maturation of young human beta cells — the ...

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...