A study published in mBio details the vulnerability of coronaviruses to inhibitors of a small protein domain called Mac1, or the "macrodomain," found in all coronaviruses such as SARS-CoV-2 and ...

The story so far: A two-year-old child in Tikrikilla, Meghalaya, has been infected with vaccine-derived polio. This is not a case of wild poliovirus, but an infection that presents in some people ...

Prior to nasal administration of the live-attenuated flu vaccine candidate, NS1 (1-126)-ΔPAX, the animals were primed using a vesicular stomatitis virus (VSV) as a vaccine delivery mechanism.

In particular, live, attenuated vaccines contain a live but weakened version of a virus or bacteria, while inactivated vaccines contain an inactivated version of a virus or bacteria. "Many years ...

The inactivated vaccine protects against paralysis. The oral vaccine, still used in many countries, is an attenuated vaccine, made with live but weakened poliovirus.

Officials said during the conference that the U.S. stopped using the oral polio vaccine (OPV) in 2000 — and instead uses the inactivated polio vaccine (IPV), which does not contain the live virus.

All the influenza vaccines (inactivated, recombinant and live attenuated) available in the United States during the 2021-22 flu season are quadrivalent. That means they contain four components to ...

Vaccine shedding is when components of a vaccine are released into the body or out into the environment. This can only happen in live-attenuated vaccines that contain a weakened form of a pathogen ...

Live-attenuated vaccines differ from traditional inactivated vaccines where the pathogen is “killed”, and as the name suggests the pathogen (typically a virus) remains active in live vaccines ...

One of the biggest determinants of attenuation is a point mutation, 481A, in a noncoding region of the poliovirus known as domain V, or domV, that destabilizes the virus’s translation mechanism ...

The live attenuated virus first infected the intestine, and elicited both IgG- and IgA-type antibodies. (IgG protects the blood and IgA protects surfaces of organs.) ...