For instance, PDE4A appears to act as an oncogene in hepatocellular carcinoma cell line Huh7 (38), whereas it exhibits tumor-suppressive effects in HepG2 and BEL7402 cells (39). Thus, the PDE4/cAMP ...

Background Chronic inflammation and elevated reactive oxygen species are key contributors to hepatocellular carcinoma (HCC) ...

The mitochondrial calcium uniporter channel (MCUC) mediates mitochondrial calcium entry, regulating energy metabolism and cell death. Although several MCUC components have been identified, the ...

ACVR2A downregulation disrupts the TCF7/c-JUN pathway, impairing trophoblast invasion and proliferation in pre-eclampsia, revealing a genetic susceptibility-associated mechanism of placental ...

Neither MALT1 nor Roquin-1 knockout (KO) significantly influenced GPX4 expression in mouse embryonic fibroblasts (MEFs) or Huh7 and SK-HEP-1 liver cancer cells (Fig. 1 B and C). Furthermore, Roquin-1 ...

Hazardous chemicals in building and construction plastics can lead to health risks due to indoor exposure and may contaminate recycled materials. We systematically sampled new polyvinyl chloride ...

The constant advent of major health threats such as antibacterial resistance or highly communicable viruses, together with a declining antimicrobial discovery, urgently requires the exploration of ...

Because of the exquisite sensitivity of these cell lines to induction of ferroptosis, we were unable to generate stable CRISPR knockout clones for MALT1 in either Huh7 or SK-Hep1 cells. Given that ...