A recent study published in eLife has uncovered a crucial mechanism in cellular material management: endosome maturation. The research team was led by Dr. Ding Mei and Dr. He Kangmin from the ...

E ndosomes, small lipid vesicles that sort and traffic biomolecules between other subcellular compartments and organelles, are critical to a cell’s internal transport network and overall function.

Still, mechanistic mysteries remain. “How impaired endosome maturation leads to the formation of TDP-43 inclusions in the cytoplasm and nuclear depletion, whatever comes first, are still important ...

Furthermore, this study indicates that gradual accumulation of lipid nanoparticles in large endosomes leads to impaired acidification, inhibition of maturation, and disrupted mRNA delivery.

On a daily basis, multitudes of molecules enter each cell in our body. These can be nutrients or signal molecules or pathogenic microorganisms. An organelle in the cell directs these molecules to ...

We demonstrate the ability of this DNA nanomachine to function inside living cells by using it to map spatio-temporal pH changes associated with endosome maturation. Our studies show that it is able ...

A drug that inhibits endosome maturation blocked infection in vitro. The next step is to validate all of our findings in vivo. Can it be that a few neurons in our brain are infected for a long time ...

The vesicle is then quickly merged with an endosome, an organelle also frequently referred to as a “sorting station”. From the endosome, the substance is either recycled back to the cell membrane (for ...

Escaping the endosome. Unfortunately, even when LNPs reach their target cells, the nanoparticles are typically captured by endosomes—tiny protective sacs within the cell.