Taken together, the results propose “two novel pathways in which GSK3β phosphorylation events exacerbate and ERK phosphorylation events mitigate HD-dependent neuronal dysfunction, highlighting ...

Cheryl (Cheri) Erk, 66, of Richmond, Virginia passed away peacefully surrounded by family on Tuesday, February 11th, 2025. She is preceded by her mother, Julia McGrath, and father, James McGrath.

In cultured human endothelial cells, the agonist-induced phosphorylations of eNOS (Ser1177) and the upstream kinases, such as calcium/calmodulin-dependent protein kinase II (CaMKII) (Thr286) and ...

Jennifer Klomp and colleagues 7 used advanced mass-spectrometry techniques to map the ERK-dependent phosphoprotein network by measuring changes in protein-specific phosphorylation in pancreatic ...

“So we could get Erk in the College Football Hall of Fame.” Belue’s favorite memory with Russell occurred after the 1980 Georgia-Florida game, when Lindsay Scott infamously took a crossing ...

From John Krasinski to Denzel Washington to Brad Pitt, look back at all the Sexiest Man Alive in their earlier days to now ...

The key DNA repair enzyme DNA-PKcs has several and important cellular functions. Loss of DNA-PKcs activity in mice has revealed essential roles in immune and nervous systems. In humans, DNA-PKcs is a ...

Yet CaMKII is present in nearly every other cell. The review offers insights into the protein for those who don't study it fulltime, providing tools to fill in the gaps in knowledge about how the ...

Journal Reference: Carolyn Nicole Brown, Karl Ulrich Bayer. Studying CaMKII: Tools and standards. Cell Reports, 2024; 43 (4): 113982 DOI: 10.1016/j.celrep.2024.113982 ...

CaMKII Role: The CaMKII protein is essential in learning, memory, and heart function, but its misregulation can lead to serious health issues. Drug Inhibitors: Three distinct classes of drug ...

Ruiz, V., et al. (2024). Dual inhibition of MEK and PI3Kβ/δ–a potential therapeutic strategy in PTEN-wild-type docetaxel-resistant metastatic prostate cancer. Frontiers in Pharmacology. doi ...