Overwhelmingly, the selectivity of NSAIDs is based on an IC 50 value (the concentration at which an NSAID produces 50% inhibition of COX-1 and/or COX-2).

This simplistic division of the roles of COX-1 and COX-2 drove the search for 'selective' COX-2 inhibitors and further fuelled the ranking of NSAIDs in terms of their relative selectivity for COX ...

Background Prostanoid synthesis is catalysed by two distinct cyclooxygenase (COX) isoforms; COX-1 (constitutive) and COX-2 (inducible). NSAIDs such as aspirin, ibuprofen and indomethacin inhibit both ...

Based on the COX dogma, that COX-1 is good and COX-2 is bad , we were promised equal therapeutic efficacy to conventional non-steroidal inflammatory drugs (NSAIDs) with the COX-2 selective inhibitors ...

NSAIDs stop proteins called cyclooxygenase, known as COX, and fall into two classes: “selective” COX-2 inhibitors (celecoxib, etoricoxib, or rofecoxib) and “nonselective” COX-1/COX-2 ...

Objective To assess the comparative efficacy of traditional non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclo-oxygenase-2 inhibitors in patients with acute gout. Design Systematic ...

The frequent use of nonsteroidal anti-inflammatory drugs (NSAID) in combination with gentamicin poses the additional risk of nephrotoxic renal failure. Cyclooxygenase-1 (COX-1) is the main enzyme ...

BACKGROUND Acute and chronic use of non-steroidal anti-inflammatory drugs can increase intestinal permeability. Rofecoxib, which selectively inhibits cyclooxygenase 2 (COX-2), is a novel ...

Doctors compare household painkillers like ibuprofen and acetaminophen, explaining their mechanisms and when each works best ...

An iterative parallel synthesis effort identified a PLD2 selective inhibitor, ML298 (PLD1 IC50 > 20 000 nM, PLD2 IC50 = 355 nM) and a dual PLD1/2 inhibitor, ML299 (PLD1 IC50 = 6 nM, PLD2 IC50 = 20 nM) ...