There are several difficulties in using RCT data to study the increased risk of cardiovascular events in patients taking COX-2-selective NSAIDs. None of these RCTs, which were primarily conducted ...

rcsi.ie BACKGROUND Selective inhibitors of cyclooxygenase (COX)-2 may provoke less gastric damage and platelet inhibition than conventional non-steroidal anti-inflammatory drugs. AIMS We compared the ...

health.wa.gov.au There has been a great deal written about the use of selective cyclo-oxygenase ... literature on the use of COX-2 inhibitors in children. The major mechanism of action of ...

They act by blocking the formation of both prostaglandins and leucotrienes but do not affect lipoxin formation. Such combined inhibition avoids some of the disadvantages of selective COX-2 inhibitors ...

It differs from non-selective NSAIDs because it targets the COX-2 enzyme, primarily involved in inflammation. Celebrex works ...

The original NSAIDs are called salicylates, which includes aspirin. Nonacetylated salicylates don’t contain aspirin and are designed to have fewer side effects. Selective COX-2 inhibitors were ...

In 2004, the very popular selective COX-2 inhibitor Vioxx (rofecoxib) was pulled from the market over concerns about an increased risk of heart attacks and stroke. Considering NSAID Risks and ...

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to prevent NSAID-related stomach concerns, talk to your doctor about the following options: Switch to another drug (such as a COX-2 selective inhibitor) Switch to the lowest dosage Consider ...

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...

[77] Intuitively, the combination of a COX-2-selective NSAID plus a proton pump inhibitor (PPI) should provide effective analgesia and further decrease the risk of upper-GI events compared to a ...