Patients with osteoarthritis or rheumatoid arthritis have traditionally been treated with NSAIDs, but these drugs are associated with a significant risk of upper gastrointestinal clinical events. PPIs ...

More recent cost-effective analyses have examined cardiovascular risk and GI benefit, together, adding the assumption that aspirin mitigates the gastroprotective effects of COX-2-selective NSAIDs. For ...

Patients with gastroesophageal reflux disease who are compliant with proton pump inhibitor therapy stay on NSAIDs longer than noncompliant patients. Study subjects were GERD patients receiving ...

Objective To assess the effects of selective cyclo-oxygenase-2 (COX 2) inhibitors and traditional non-steroidal anti-inflammatory drugs (NSAIDs) on the risk of vascular events. Design Meta-analysis of ...

COX-2/COX-1 ratios of a range of NSAIDs were discussed, and there appears to be a strong correlation between the COX-2/COX-1 ratios and epidemiological data for GI disorders. Side effects of ...

The FDA issued a public health advisory on Thursday summarizing the agency’s recommendations concerning the use of non-steroidal anti-inflammatory drug products (NSAIDs), including COX-2 drugs, both ...

The nonsteroidal anti-inflammatory drugs (NSAIDs) are believed to mediate their anticancer effects by inducing apoptosis but the molecular mechanisms of their apoptotic effects remain largely unknown.

This issue of examines interventions aimed at improvingdrug safety. 1-4 The need for a rigorous researchagenda in pharmaceutical safety is highlighted byMerck's ...

Since the early 2000s, a large body of scientific research has demonstrated an association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and an increased risk of cardiovascular ...

Dr. Berchman Austin Vaz answers the question: 'NSAIDs For Osteoarthritis Pain?' — -- Question: What is an NSAID and how is it used to treat pain resulting from osteoarthritis? Answer: NSAIDs are ...

The COX enzyme is required for the rate-limiting step of converting arachidonic acid into prostaglandins, which are inflammatory mediators. There are two well-recognized isoforms of COX: COX-1 and COX ...

The Food and Drug Administration on Thursday ordered the painkiller Bextra off the market and wants similar prescription drugs to carry the strongest possible warnings about increased risk of heart ...