BTK inhibitors, including the commonly used drug ibrutinib, block B cells' signaling pathway. This is helpful for treating B-cell lymphomas because the cancers arise when this signaling pathway ...

Drugs that specifically inhibit BCR signaling elements ... receptor-activation pathways following antigenic stimulation. BCR: B-cell receptor; BLNK: B-cell linker protein; BTK: Bruton's tyrosine ...