Compared to placebo (a sham medication), tirzepatide likely helps adults with obesity lose weight in the medium term (up to 2 years), and this weight reduction is likely to be maintained over the long ...

We wanted to find out if oral nicotine pouches can help people transition away from smoking, nicotine vaping, or other forms of tobacco use. We also wanted to know if oral nicotine pouches caused any ...

Liraglutide compared with placebo (a sham medication) likely increases the number of people who lose at least 5% of their body weight, but its impact on unwanted effects, quality of life, and major ...

Adults with obesity lose more weight with semaglutide than with placebo (a sham medication). However, the risk of unwanted events is probably higher than with placebo after 24 months. Semaglutide ...

In people with cancer, CBT-I may slightly improve insomnia severity, sleep quality, and most sleep diary parameters without introducing additional unwanted or harmful events. However, we are very ...

Sedation using propofol instead of traditional sedatives may improve recovery time and patient satisfaction scores for people undergoing colonoscopy. Propofol sedation has little to no effect on ...

Side effects of acupuncture include dizziness, nausea, bruising, insomnia, abdominal pain, and skin rashes, which should be considered when weighing potential benefits and risks.

• Antibiotics seem to reduce surgical site infections in people undergoing surgery to fix the lower limb arteries (peripheral arterial reconstruction of the lower limb).

Molnupiravir is a pill used to treat COVID-19 in people who are at high risk of developing severe illness. It works by interfering with the ability of SARS‑CoV‑2 (the virus that causes COVID-19) to ...

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Why systematic and rigorous searches are important, planning and designing search strategies, sources of studies, managing and reporting the process.

Here we list specialized resources for other methods that Cochrane Groups have produced. Clinical study reports and other regulatory documents Clinical study reports (CSRs) are documents submitted to ...