Signal transduction across membranes through regulated intramembrane proteolysis is conserved throughout all domains of life. In the SREBP pathway of human cells, the membrane-bound SREBP ...

Tuberculosis remains a major global health threat, and symptom-based case detection fails to interrupt community transmission.1 Nearly half of tuberculosis cases are missed by current strategies, and ...

A histone acetylome-wide associations study (HAWAS) performed in immune cells from patients with active Mycobacterium tuberculosis infection versus those from healthy controls, has for the first time ...

Mycobacterial diseases, including tuberculosis (TB), leprosy, and non-tuberculous mycobacterial (NTM) infections, continue to impose a substantial global ...

Mammalian hosts coordinate various cell death pathways as part of the immune defense system against pathogens including Mycobacterium tuberculosis (Mtb), which causes tuberculosis featuring lung ...

It has been uncertain how Mycobacterium tuberculosis deflects the immune response in humans, though evidence has pointed to host immunometabolism—the intrinsic link between metabolism in immune cells ...

Mycobacterium tuberculosis (M. tuberculosis) is a bacterium that causes tuberculosis (TB) in humans. TB is a disease that primarily affects the lungs, although it can attack other parts of the body.

A consortium of researchers from Russia, Belarus, Japan, Germany and France led by a Skoltech scientist have uncovered the way in which Mycobacterium tuberculosis survives in iron-deficient conditions ...

It has been uncertain how Mycobacterium tuberculosis deflects the immune response in humans, though evidence has pointed to host immunometabolism - the intrinsic link between metabolism in immune ...