What’s at stake, who’s better, key matchup to watch, TV info, fantasy sleeper and prediction for Sunday’s home game between the AFC West rivals.

Payton needs one victory to tie Bill Parcells for the 16th-most regular-season wins in NFL history. Payton springs off of the Parcells coaching tree, so this will be a sweet and symbolic achievement for the Broncos' head coach. Let's hope it happens at SoFi Stadium.

The Denver Broncos (1-1) are hitting the road this week for an AFC West showdown with the Los Angeles Chargers (2-0). Ahead of that matchup, check out NFL.com's video preview (and expert game picks) below. Following the Chargers game, up next on the Broncos' schedule is a home Monday Night Football clash with the Cincinnati Bengals in Week 4.

Here are five predictions for Sunday’s pivotal game at SoFi Stadium: The Chargers’ rookie out of North Carolina is a powerful and fast player who could not get untracked last week against the Raiders. Najee Harris didn’t fare much better as Justin Herbert led the Chargers in rushing.

The Broncos have ruled out a pair of players for Sunday's divisional matchup. How to watch, listen to and live stream the Broncos' Week 3 matchup against the Los Angeles Chargers on Sunday, Sept. 21, 2025.

Preview the Denver Broncos' NFL Week 3 matchup with the Chargers, including live stream, TV channel, odds, and game information.

The Denver Broncos (1-1) and LA Chargers (2-0) meet in a divisional face-off Sunday. Kickoff from SoFi Stadium in Inglewood, California, is set for 4:05 p.m. ET (CBS). Let's analyze BetMGM Sportsbook's NFL odds around the Broncos vs. Chargers odds and make our expert NFL picks and predictions for the best bets.

The Denver Broncos and Los Angeles Chargers will face off in an AFC West matchup in Week 3. The Chargers have already beaten two division rivals in the Kansas City Chiefs and Las Vegas Raiders.

The Indianapolis Colts beat the Denver Broncos in NFL Week 2 action: Live score updates, stats, highlights, injuries.

As the Denver Broncos prepare to relocate to a new venue, business owners near Empower Field are facing mixed emotions.

Los Angeles is a 2.5-point favorite in the latest Broncos vs. Chargers odds from SportsLine consensus, while the over/under for total points scored is 46. The Chargers are -154 money line favorites (risk $154 to win $100),